Motif ID: DMAP1_NCOR{1,2}_SMARC.p2

Z-value: 1.800


Transcription factors associated with DMAP1_NCOR{1,2}_SMARC.p2:

Gene SymbolEntrez IDGene Name
DMAP1 55929 DNA methyltransferase 1 associated protein 1
NCOR1 9611 nuclear receptor co-repressor 1
NCOR2 9612 nuclear receptor co-repressor 2
SMARCA1 6594 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCA5 8467 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC2 6601 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMARCA1chrX_-_128657453-0.511.6e-15Click!
SMARCA5chr4_+_1444345550.321.8e-06Click!
SMARCC2chr12_-_56583301-0.211.8e-03Click!
NCOR1chr17_-_159737600.203.4e-03Click!
NCOR2chr12_-_125052009-0.036.4e-01Click!


Activity profile for motif DMAP1_NCOR{1,2}_SMARC.p2.

activity profile for motif DMAP1_NCOR{1,2}_SMARC.p2


Sorted Z-values histogram for motif DMAP1_NCOR{1,2}_SMARC.p2

Sorted Z-values for motif DMAP1_NCOR{1,2}_SMARC.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of DMAP1_NCOR{1,2}_SMARC.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_15114495 48.328 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_-_29641087 46.273 EVI2B
ecotropic viral integration site 2B
chr1_+_198608216 46.190 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_-_39826676 43.645 NM_004877
GMFG
glia maturation factor, gamma
chr19_-_39826625 41.101 GMFG
glia maturation factor, gamma
chr1_-_150738232 37.404 CTSS
cathepsin S
chr1_-_150738255 35.867 CTSS
cathepsin S
chr1_+_198608136 34.883 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr7_+_74188308 34.013 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr6_+_29691116 33.319 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr18_-_51690988 32.364 MBD2
methyl-CpG binding domain protein 2
chr2_+_143886969 32.025 ARHGAP15
Rho GTPase activating protein 15
chr2_+_143886898 31.352 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr1_-_150738292 30.413 NM_001199739
NM_004079
CTSS

cathepsin S

chr5_-_169724734 27.402 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_169724782 26.376 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_149792276 25.925 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr11_-_104905849 25.418 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr7_-_115670828 24.711 NM_001018058
NM_012252
TFEC

transcription factor EC

chr5_-_169724817 24.270 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 102 entries
enrichment   p-value GO term description
5.28 1.96e-04 GO:0030217 T cell differentiation
4.14 5.72e-04 GO:0030098 lymphocyte differentiation
4.07 1.45e-02 GO:0050852 T cell receptor signaling pathway
4.02 9.77e-05 GO:0042110 T cell activation
3.75 9.90e-03 GO:0050851 antigen receptor-mediated signaling pathway
3.67 6.85e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
3.53 1.18e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
3.42 1.36e-05 GO:0046649 lymphocyte activation
3.34 7.84e-03 GO:0002521 leukocyte differentiation
3.32 8.41e-07 GO:0045321 leukocyte activation
2.94 7.73e-03 GO:0002757 immune response-activating signal transduction
2.92 3.04e-17 GO:0006955 immune response
2.87 6.50e-07 GO:0044419 interspecies interaction between organisms
2.87 1.15e-02 GO:0002764 immune response-regulating signaling pathway
2.75 4.66e-04 GO:0048534 hemopoietic or lymphoid organ development
2.74 4.47e-06 GO:0045087 innate immune response
2.74 2.16e-04 GO:0050778 positive regulation of immune response
2.73 2.66e-02 GO:0019221 cytokine-mediated signaling pathway
2.71 2.83e-04 GO:0002520 immune system development
2.69 4.06e-03 GO:0030097 hemopoiesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
3.09 3.68e-03 GO:0043235 receptor complex
2.01 2.28e-03 GO:0030529 ribonucleoprotein complex
1.87 8.57e-08 GO:0005654 nucleoplasm
1.77 9.16e-03 GO:0044451 nucleoplasm part
1.66 1.23e-06 GO:0031981 nuclear lumen
1.62 4.44e-07 GO:0044428 nuclear part
1.53 7.33e-05 GO:0005829 cytosol
1.52 2.08e-05 GO:0031974 membrane-enclosed lumen
1.51 3.72e-05 GO:0043233 organelle lumen
1.47 4.19e-04 GO:0070013 intracellular organelle lumen
1.45 3.87e-07 GO:0032991 macromolecular complex
1.42 1.36e-04 GO:0043234 protein complex
1.39 1.07e-10 GO:0005634 nucleus
1.25 8.23e-04 GO:0044422 organelle part
1.24 1.35e-03 GO:0044446 intracellular organelle part
1.19 3.27e-05 GO:0043227 membrane-bounded organelle
1.19 4.14e-05 GO:0043231 intracellular membrane-bounded organelle
1.17 3.64e-05 GO:0043226 organelle
1.17 4.09e-05 GO:0043229 intracellular organelle
1.16 1.05e-07 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
6.00 5.95e-04 GO:0003823 antigen binding
5.04 2.61e-02 GO:0004715 non-membrane spanning protein tyrosine kinase activity
3.23 1.60e-02 GO:0019955 cytokine binding
3.01 5.16e-03 GO:0003714 transcription corepressor activity
2.44 1.49e-03 GO:0008134 transcription factor binding
2.13 4.29e-02 GO:0016563 transcription activator activity
1.90 1.50e-03 GO:0043565 sequence-specific DNA binding
1.88 2.44e-04 GO:0003723 RNA binding
1.67 5.02e-03 GO:0030528 transcription regulator activity
1.53 1.22e-05 GO:0003677 DNA binding
1.45 3.23e-06 GO:0003676 nucleic acid binding
1.44 1.45e-21 GO:0005515 protein binding
1.18 2.95e-12 GO:0005488 binding